|
|
phosphatidylinositol + a_very-long-chain_mannosylinositol_phospho-(2'R)-2'-hydroxyphytoceramide <=> a_very-long-chain_mannosyl-diphosphoinositol-(2'R)-2'-hydroxyphytoceramide + diacylglycerol
|
2.7.1.228
mannosyl-inositol-phosphoceramide inositolphosphotransferase
|
–
|
| |
BRENDA:
BR52925
MetaCyc:
RXN3O-680
|
|
|
|
stearoyl-CoA + L-serine + H+ <=> (S)-2-amino-1-hydroxyeicosane-3-one + CO2 + CoA
|
2.3.1.50
serine C-palmitoyltransferase
|
–
|
| |
BRENDA:
BS420887
MetaCyc:
RXN-20396
|
|
|
|
very-long-chain_phytoceramide + O2 + ferricytochrome_b5 + H+ <=> very-long-chain_(2''R)-2''-hydroxy-phytoceramide + H2O + ferricytochrome_b5
|
1.14.18.6
4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase
|
–
|
| |
MetaCyc:
RXN-20394
|
|
|
|
behenoyl-CoA + phytosphingosine <=> very-long-chain_phytoceramide + CoA + H+
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
| |
MetaCyc:
RXN3O-328
|
|
|
|
GDP-mannose + IpC <=> a_very-long-chain_mannosylinositol_phospho-(2'R)-2'-hydroxyphytoceramide + GDP + H+
|
2.4.1.370
inositol phosphorylceramide mannosyltransferase
|
–
|
| |
BRENDA:
BR52835
KEGG:
R12472
MetaCyc:
RXN3O-663
|
|
|
|
palmitoyl-CoA + L-serine + H+ <=> 3-dehydrosphinganine + CO2 + CoA
|
2.3.1.50
serine C-palmitoyltransferase
|
–
|
| |
BRENDA:
BR44052
KEGG:
R01281
MetaCyc:
SERINE-C-PALMITOYLTRANSFERASE-RXN
|
|
|
|
sphinganine + NADP+ <=> 3-dehydrosphinganine + NADPH + H+
|
1.1.1.102
3-dehydrosphinganine reductase
|
–
|
| |
BRENDA:
BR29168
KEGG:
R02978
MetaCyc:
3-DEHYDROSPHINGANINE-REDUCTASE-RXN;
RXN-20505
|
|
|
|
sphinganine + O2 + ferricytochrome_b5 + H+ <=> phytosphingosine + H2O + ferricytochrome_b5
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
| |
KEGG:
R06525
MetaCyc:
RXN3O-1380
|
|
|
|
(S)-2-amino-1-(R)-3-dihydroxyeicosane + O2 + ferricytochrome_b5 + H+ <=> 4-hydroxyeicosasphinganine + H2O + ferricytochrome_b5
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
| |
MetaCyc:
RXN-20397
|
|
|
|
phosphatidylinositol + very-long-chain_(2''R)-2''-hydroxy-phytoceramide <=> diacylglycerol + IpC
|
2.7.1.227
inositol phosphorylceramide synthase
|
–
|
| |
BRENDA:
BR52924
MetaCyc:
RXN3O-581
|
|
|
|
(S)-2-amino-1-(R)-3-dihydroxyeicosane + NADP+ <=> (S)-2-amino-1-hydroxyeicosane-3-one + NADPH + H+
|
1.1.1.102
3-dehydrosphinganine reductase
|
–
|
| |
BRENDA:
BS186955
MetaCyc:
RXN-12642
|
|
